diff --git a/.local/bin/tmux-open-path b/.local/bin/tmux-open-path
new file mode 100755
index 0000000..95a6683
--- /dev/null
+++ b/.local/bin/tmux-open-path
@@ -0,0 +1,67 @@
+#!/usr/bin/env zsh
+# Open the file path under the mouse in a tmux pane, routed by type:
+#   markdown        -> Markdown Preview (GUI)
+#   images, pdf, dirs -> yazi in a split pane (image preview via passthrough)
+#   anything else   -> nvim in a split pane, jumping to :line when present
+#
+# Called from a tmux mouse binding:
+#   tmux-open-path <pane_id> <pane_current_path> <mouse_x> <mouse_line>
+
+emulate -L zsh
+setopt extendedglob
+
+pane=$1 cwd=$2 x=$3 line=$4
+
+fail() { tmux display-message -d 2000 "open-path: $1"; exit 1 }
+
+[[ -n $pane && -n $cwd && $x == <-> ]] || fail "usage: tmux-open-path PANE CWD X LINE"
+
+# Grab the run of path-like characters around the clicked column. Whitespace,
+# quotes, brackets and box-drawing borders end a token.
+local stop=$' \t"\'`()[]{}<>|│┃║─━'
+(( i = x + 1 ))   # mouse_x is 0-based, zsh strings are 1-based
+(( i <= ${#line} )) || fail "nothing under cursor"
+[[ $stop == *${line[i]}* ]] && fail "nothing under cursor"
+(( s = i )); while (( s > 1 )) && [[ $stop != *${line[s-1]}* ]]; do (( s-- )); done
+(( e = i )); while (( e < ${#line} )) && [[ $stop != *${line[e+1]}* ]]; do (( e++ )); done
+token=${line[s,e]}
+
+# Normalise: file:// URLs, @mentions, trailing punctuation, :line[:col], #Lnn.
+token=${token#file://}
+token=${token#@}
+token=${token%%[.,;:!?]##}
+lnum=
+if [[ $token == (#b)(*)\#L(<->)* ]]; then
+    token=$match[1] lnum=$match[2]
+elif [[ $token == (#b)(*):(<->):<-> || $token == (#b)(*):(<->) ]]; then
+    token=$match[1] lnum=$match[2]
+fi
+[[ -n $token ]] || fail "nothing under cursor"
+
+# Resolve against the pane's directory, then the enclosing git root.
+token=${~token}   # expand a leading ~
+# (not "path": zsh ties that name to $PATH)
+file=
+if [[ $token == /* ]]; then
+    [[ -e $token ]] && file=$token
+else
+    for base in $cwd $(git -C $cwd rev-parse --show-toplevel 2>/dev/null); do
+        [[ -e $base/$token ]] && { file=$base/$token; break }
+    done
+fi
+[[ -n $file ]] || fail "no such file: $token"
+file=${file:A}
+
+if [[ -d $file ]]; then
+    tmux split-window -h -t $pane -c $file "yazi ${(q)file}"
+    exit
+fi
+
+case ${file:e:l} in
+    md|markdown|mdx|mdown|mkd|mkdn)
+        open -a "Markdown Preview" $file ;;
+    png|jpg|jpeg|gif|webp|avif|svg|bmp|tif|tiff|heic|ico|pdf)
+        tmux split-window -h -t $pane -c ${file:h} "yazi ${(q)file}" ;;
+    *)
+        tmux split-window -h -t $pane -c $cwd "nvim ${lnum:++$lnum} ${(q)file}" ;;
+esac
diff --git a/.tmux.conf b/.tmux.conf
index c65dbe4..e54fd63 100644
--- a/.tmux.conf
+++ b/.tmux.conf
@@ -142,6 +142,11 @@ bind-key -T copy-mode-vi 'C-\' select-pane -l
 set -g set-clipboard on
 set -as terminal-features ',*:clipboard'
 
+# Ctrl+click a file path in any pane (omo, shell, logs) to open it:
+# markdown in Markdown Preview, images/pdf/dirs in yazi, the rest in nvim.
+# yazi and nvim split beside the clicked pane. See ~/.local/bin/tmux-open-path.
+bind -n C-MouseDown1Pane run-shell -b "~/.local/bin/tmux-open-path #{q:pane_id} #{q:pane_current_path} #{mouse_x} #{q:mouse_line}"
+
 #
 # Initialize TMUX plugin manager (keep this line at the very bottom of tmux.conf)
 run '~/.tmux/plugins/tpm/tpm'
diff --git a/Brewfile.apps b/Brewfile.apps
index 97c5193..c292261 100644
--- a/Brewfile.apps
+++ b/Brewfile.apps
@@ -20,6 +20,7 @@ cask "charles"
 cask "cyberduck"
 cask "chromium"
 cask "johannesnagl/tap/showmd", trusted: true
+cask "markdown-preview"
 
 # AI and agents
 cask "conductor"
diff --git a/README.md b/README.md
index 7f86609..7f10034 100644
--- a/README.md
+++ b/README.md
@@ -158,7 +158,7 @@ Key features:
 
 ### Development Tools
 
-- **tmux** (`.tmux.conf`): Terminal multiplexer with custom key bindings; sets the terminal title to the session name, after the omo status marker when there is one
+- **tmux** (`.tmux.conf`): Terminal multiplexer with custom key bindings; sets the terminal title to the session name, after the omo status marker when there is one. Ctrl+click a file path in any pane (omo, a shell, logs) to open it with `tmux-open-path`: markdown in Markdown Preview, images, PDFs and directories in yazi, anything else in nvim at the clicked `:line`. yazi and nvim open in a split beside the clicked pane
 - **Zed** (`.config/zed/keymap.json`): Editor key bindings. Settings stay local because they reference machine-specific agent paths
 - **tmux server** (`.tmux-server.conf`): Lightweight tmux config for remote servers
 - **Git**: Global gitignore patterns (`.rgignore`, `.gitignore`)
@@ -232,6 +232,7 @@ Custom scripts and binaries are stored in `.local/bin/`:
 - `claude-tmux`: Claude integration with tmux
 - `cldir`: Change directory with Claude context
 - `owt`: Git worktree workspaces for coding agents (see [Agent workspaces](#agent-workspaces-owt))
+- `tmux-open-path`: Backs tmux's Ctrl+click. Takes the path under the mouse, strips `:line:col`, `#L10`, `@` and `file://`, resolves it against the pane's directory and then its git root, and routes it by type: markdown to Markdown Preview (`cask "markdown-preview"` in `Brewfile.apps`), images, PDFs and directories to yazi, the rest to nvim
 - `omo-notify`: Sound, tab marker and notification for OmO's hooks. Ghostty posts the notification, so clicking it opens the session's tab and pane
 - `omo-status`: Coloured marker in front of the Ghostty tab title for each tmux session running omo: 🔴 stopped with an error, 🟡 waiting for your answer, 🟢 finished, 🔵 working. A tab with several agents shows the most urgent one; focusing the tab clears red, amber and green, and undoes any title you gave the tab by hand so it always shows its session name
 - `docker-nuke`: Force-restart a wedged Docker Desktop, capturing diagnostics to `~/.local/state/docker-nuke/` first (`--dry-run` to preview, `--no-restart` to leave it down, `--deep` for root helpers)